Major Crash detectives are investigating a serious collision in Perth’s south that has killed two men.

Police say a Suzuki motorbike and a Nissan ute crashed at the intersection of Surf Drive and Warnbro Sound Avenue in Secret Harbour around 5.30 yesterday afternoon.

Both the rider, a 20 year-old man, and the driver of the car, a 32 year-old man, died at the scene.

A 12 year-old girl and a 4 year-old boy, who were passengers in the ute, escaped serious injuries.

Press PLAY to hear all the current news

Millsy and Karl also discussed: the budget Preview; John Farnham’s health update; kids helpline struggling; and Barry Humphries’ funeral.

Image: Nine News